Collagen epitope expression on B cells is sufficient to confer tolerance to collagen-induced arthritis
Arthritis Research & Therapy(2016)
摘要
The mechanisms underlying tolerance induction and maintenance in autoimmune arthritis remain elusive. In a mouse model of rheumatoid arthritis, collagen type II (CII)-induced arthritis, we explore the contribution of B cells to antigen-specific tolerance.
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关键词
Tolerance,B cells,B lymphocytes,Arthritis,Collagen,Collagen type II,Gene therapy,Antigen presentation
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