Network propagation: a universal amplifier of genetic associations

Key Points Network propagation transforms a short list of candidate genes into a genome-wide profile of gene scores that are based on proximity to candidates in a gene network. This transformation greatly improves the power of genetic association, providing a universal amplifier for genetic analysis. Mathematically, the technique of network propagation is simplifying and unifying. Network propagation methods can be used to identify genes and genetic modules that underlie human disease.