Streptozocin-induced Type-1 diabetes mellitus results in decreased density of cgrp sensory and th sympathetic nerve fibers that are positively correlated with bone loss at the mouse femoral neck.

Iris A Enríquez-Pérez, Karla E Galindo-Ordoñez, Christian E Pantoja-Ortíz,Arisaí Martínez-Martínez, Rosa I Acosta-González,Enriqueta Muñoz-Islas,Juan M Jiménez-Andrade

Neuroscience Letters（2017）

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摘要

•Type-1 DM decreases the density of CGRP and TH nerve fibers in the mouse femur.•Type-1 DM negatively alters the trabecular bone at the mouse femoral neck.•Density of CGRP fibers is positively correlated to trabecular bone microarquitecture.•Density of TH fibers is positively correlated to trabecular bone microarquitecture.

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关键词

BV/TB,CGRP,DA,IGF,MicroCT,NGF,STZ,T1DM,T2DM,tBMD,Tb.N,Tb.Sp,Tb.Th,TH,TNF alpha

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