Industrial medicinal chemistry insights: neuroscience hit generation at Janssen.

Gary Tresadern,Frederik J R Rombouts,Daniel Oehlrich,Gregor Macdonald,Andres A Trabanco

Drug Discovery Today（2017）

引用 5|浏览34

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摘要

•Modern medicinal Chemistry is highly multidisciplinary.•Chemistry can provide drug discovery innovation in many ways.•A dedicated team was established to explore new areas and hit generation.•Impact over many areas including fragment screening, novel synthesis, delivery.

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关键词

CADD,FBDD,drug discovery,ligand efficiency,medicinal chemistry,organic chemistry

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