Estrogens and the cognitive symptoms of schizophrenia: possible neuroprotective mechanisms.

Claire McGregor,Alexander Riordan,Janice Thornton

Frontiers in Neuroendocrinology（2017）

引用 63|浏览24

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摘要

•Sex differences in schizophrenia indicate that estrogens play a protective role.•Cognitive dysfunction is correlated to functional outcome.•Treatment with estrogens may improve cognitive symptoms.•Potential sites of action include NMDA receptors, GABA receptors, inflammation, BDNF, and LH.

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关键词

Schizophrenia,Estrogen,Cognitive deficits,Neuroprotection,NMDA receptor hypofunction,GABA,Neuroinflammation,Luteinizing hormone,BDNF

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