Connexin hemichannel inhibition reduces acetaminophen-induced liver injury in mice.

Michaël Maes,Sara Crespo Yanguas,Joost Willebrords,James L Weemhoff,Tereza Cristina da Silva,Elke Decrock,Margitta Lebofsky,Isabel Veloso Alves Pereira,Luc Leybaert,Anwar Farhood,Hartmut Jaeschke,Bruno Cogliati,Mathieu Vinken

Toxicology Letters（2017）

引用 29|浏览36

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摘要

•Inhibition of connexin hemichannels by connexin mimetic peptides.•No effects of connexin mimetic peptides on gap junctions.•Cx32 hemichannel inhibition reduces ALT activity and inflammation in APAP-induced liver injury.•Cx43 hemichannel inhibition reduces inflammation in APAP-induced liver injury.•Additive effects of Cx32 and Cx43 hemichannel inhibition on APAP-induced liver injury.

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关键词

2-APB,ALT,ANOVA,APAP,ATP,CBX,Cx,ELISA,FRAP,GSH,GSSG,HBSS,IL-1β/6/10,n,NAPQI,p,SEM,TAT,TNFα

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