Drug target residence time: a misleading concept.
Drug Discovery Today(2018)
摘要
•Examples in support of the residence time literature are incomplete and misleading.•There are no examples of residence time significantly outlasting pharmacokinetics.•The importance of the on-rate in target binding is often overlooked.•Singling out residence time is a sub-optimal way to drive a drug discovery program.
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关键词
binding kinetics,off-rate,rebinding,residence time
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