Preclinical validation of 111 In-girentuximab-F(ab') 2 as a tracer to image hypoxia related marker CAIX expression in head and neck cancer xenografts.

Fokko J Huizing,Bianca A W Hoeben,Gerben Franssen,Jasper Lok,Sandra Heskamp,Egbert Oosterwijk,Otto C Boerman,Johan Bussink

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology（2017）

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摘要

In-girentuximab-F(ab') has a high affinity for CAIX. In vivo tumor uptake correlated strongly with CAIX expression in different head and neck xenografts. These results suggest that In-girentuximab-F(ab') is a promising tracer for imaging of hypoxia-related CAIX expression.

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关键词

CAIX imaging,Girentuximab,Head and neck cancer,Hypoxia,Preclinical

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