Fundamental Limits of Genome Assembly Under an Adversarial Erasure Model.

IEEE Transactions on Molecular, Biological and Multi-Scale Communications(2016)

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摘要
In contrast to second-generation DNA sequencing technologies, emerging third-generation technologies are capable of delivering reads that are long enough to enable perfect genome assembly. Unfortunately, the benefits of long reads are accompanied by higher rates of read errors. This motivates a question of fundamental import: what read-length and error-rate combinations allow for perfect assembly ...
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关键词
Genomics,Bioinformatics,Error analysis,Computational modeling,DNA,Error correction
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