A Pediatric Case of Selective Fixed Drug Eruption to Amoxicillin.

Fixed drug eruption (FDE) is a distinctive type of delayed drug hypersensitivity that presents with dermal inflammation of limited involvement recurring at the same location upon exposure to the culprit drug. It is typically characterized by an erythematous single lesion with sharp margins, even though multiple-site involvement can also occur. Appropriate testing to confirm diagnosis is still debated, although graded drug provocation test (DPT) seems to be more sensitive (1). Drugs most frequently associated with FDE include analgesics, antimalarials, barbiturates and antibiotics, including amoxicillin (2, 3). However, the evaluation of cross-reactivity of the culprit drug to others agents with similar chemical structure has been poorly studied. We present here a rare case of FDE to amoxicillin reproducible with a DPT in which we also assessed cross-reactivity with other beta-lactams both with and without identical lateral chains. This article is protected by copyright. All rights reserved.