NEAT1 scaffolds RNA-binding proteins and the Microprocessor to globally enhance pri-miRNA processing

Li Jiang,Changwei Shao,Qi-Jia Wu,Geng Chen,Jie Zhou,Bo Yang,Hairi Li,Lan-Tao Gou,Yi Zhang,Yangming Wang,Gene W Yeo,Yu Zhou,Xiang-Dong Fu

NATURE STRUCTURAL & MOLECULAR BIOLOGY（2017）

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摘要

The lncRNA NEAT1 , a key component of paraspeckles, interacts with RNA-binding proteins, including NONO and PSF, and affects global pri-miRNA processing by recruiting the Drosha–DGCR8 Microprocessor.

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关键词

Long non-coding RNAs,miRNAs,RNA,RNA metabolism,Life Sciences,general,Biochemistry,Protein Structure,Membrane Biology,Biological Microscopy

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