Polycomb-like proteins link the PRC2 complex to CpG islands

Haojie Li,Robert Liefke,Junyi Jiang,Jesse Vigoda Kurland,Wei Tian,Pujuan Deng,Weidi Zhang, Qian He,Dinshaw J. Patel,Martha L. Bulyk,Yang Shi,Zhanxin Wang

NATURE（2017）

引用 291|浏览31

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摘要

Crystal structures of the Polycomb-like proteins PHF1 and MTF2 with bound DNA and histone peptides show that extended homologous regions of the two proteins form a winged-helix structure that has an unexpected mechanism of binding to unmethylated CpG-containing DNA motifs.

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关键词

DNA methylation,Histone post-translational modifications,X-ray crystallography,Science,Humanities and Social Sciences,multidisciplinary

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