A directed evolution approach to select for novel Adeno-associated virus capsids on an HIV-1 producer T cell line.

Dawn P Wooley,Priyanka Sharma,John R Weinstein, Poornima Kotha Lakshmi Narayan,David V Schaffer,Katherine J D A Excoffon

Journal of Virological Methods（2017）

引用 7|浏览23

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摘要

•A novel AAV directed evolution approach to target parental and HIV-1-infected cells.•Triple infection of H9 T cells with AAV, adenovirus, and HIV-1 was successful.•Novel AAV capsids were isolated that show increased tropism toward the target cells.

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关键词

Directed evolution,AAV,Gene transfer,T cell,HIV-1

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