Structural basis for specific cleavage of Lys6-linked polyubiquitin chains by USP30

Yusuke Sato,Kei Okatsu,Yasushi Saeki,Koji Yamano,Noriyuki Matsuda,Ai Kaiho,Atsushi Yamagata,Sakurako Goto-Ito,Minoru Ishikawa,Yuichi Hashimoto,Keiji Tanaka,Shuya Fukai

NATURE STRUCTURAL & MOLECULAR BIOLOGY（2017）

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摘要

The structure of zebrafish DUB USP30 in complex with a Lys6-linked diUb, along with biochemistry analyses, reveals the basis for Lys6-linkage specificity.

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关键词

Enzyme mechanisms,Ubiquitylation,X-ray crystallography,Life Sciences,general,Biochemistry,Protein Structure,Membrane Biology,Biological Microscopy

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