A reversible haploid mouse embryonic stem cell biobank resource for functional genomics

Ulrich Elling,Reiner A. Wimmer,Andreas Leibbrandt,Thomas Burkard,Georg Michlits,Alexandra Leopoldi, Thomas Micheler, Dana Abdeen,Sergei Zhuk,Irene M. Aspalter,Cornelia Handl, Julia Liebergesell,Maria Hubmann,Anna-Maria Husa, Manuela Kinzer, Nicole Schuller, Ellen Wetzel, Nina van de Loo, Jorge Arturo Zepeda Martinez,David Estoppey, Ralph Riedl,Fengtang Yang,Beiyuan Fu,Thomas Dechat,Zoltán Ivics,Chukwuma A. Agu,Oliver Bell,Dieter Blaas,Holger Gerhardt,Dominic Hoepfner,Alexander Stark,Josef M. Penninger

NATURE（2017）

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摘要

The Haplobank contains over 100,000 individually reversibly mutagenized, barcoded, mouse embryonic cell lines; proof-of-principle experiments were used to search for genes that are required for rhinovirus infection and angiogenesis using forward and reverse genetic screens, respectively.

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关键词

Cell division,Cellular imaging,Stem-cell research,Science,Humanities and Social Sciences,multidisciplinary

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