Stimulation Of Signaling In Neutrophils

In this issue of Blood, Clemens et al identify specific functions of the calciumsensing molecules STIM1 and STIM2 in calcium-dependent signaling pathways in neutrophils. STIM1 is essential for the regulation of store-operated calcium entry (SOCE) and bactericidal cellular functions like phagocytosis and degranulation, whereas STIM2 is essential for neutrophil cytokine production. Protective effects of STIM2 deficiency in a mouse model of systemic inflammation make STIM2 interesting for therapeutic approaches to different inflammatory diseases.(1)