MacroH2A1.1 regulates mitochondrial respiration by limiting nuclear NAD + consumption

NATURE STRUCTURAL & MOLECULAR BIOLOGY（2017）

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摘要

Histone variant macroH2A1.1 inhibits PARP activity to maintain mitochondrial NAD + pools in muscle cells, thus linking chromatin state to optimal energy metabolism.

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关键词

Epigenetics,Histone variants,Metabolism,Life Sciences,general,Biochemistry,Protein Structure,Membrane Biology,Biological Microscopy

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