Associations between Single-Nucleotide Polymorphisms in the NTRK1 Gene and Basal Pain Sensitivity in Young Han Chinese Women.

Ningbo Li,Guangyou Duan,Jiaoli Sun,Shanna Guo,Qingli Wang,Hua Zheng,Cong Wang,Changmao Zhu,Yi Liu,Xianwei Zhang

Neuroscience Letters（2018）

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摘要

•Polymorphisms in NTRK1 play an important role in pain sensitivity in young Han Chinese women.•Four SNPs, rs1800880, rs6334, rs2644604 and rs943552, revealed a significant association with lower sharp pressure pain tolerance sensitivity.•This study provides new insights that may lead to novel approaches to individualized pain treatments in the future.

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关键词

NTRK1,Experimental pain,Pain sensitivity,Single-nucleotide polymorphism,Genotypic analysis,Young female

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