ADAM10-mediated ephrin-B2 shedding promotes myofibroblast activation and organ fibrosis

NATURE MEDICINE（2017）

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摘要

TGF-β induces expression of ADAM10, which results in greater shedding of ephrin-B2. This shedding promotes the chemotaxis and activation of myofibroblasts and thus the progression of organ fibrosis.

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Mechanisms of disease

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