DNA binding by PHF1 prolongs PRC2 residence time on chromatin and thereby promotes H3K27 methylation

NATURE STRUCTURAL & MOLECULAR BIOLOGY(2017)

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摘要
The DNA-binding activity of the winged-helix domain of PHF1 stabilizes PRC2 on chromatin, thereby permitting efficient H3K27 trimethylation.
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X-ray crystallography
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