Identification of islet-enriched long non-coding RNAs contributing to β-cell failure in type 2 diabetes.

Anna Motterle,Sonia Gattesco,Marie-Line Peyot,Jonathan Lou S Esguerra,Ana Gomez-Ruiz,D Ross Laybutt,Patrick Gilon,Frédéric Burdet,Mark Ibberson,Lena Eliasson,Marc Prentki,Romano Regazzi

Molecular Metabolism（2017）

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摘要

•Mouse pancreatic islets express a large number of novel long non-coding RNAs.•Many long non-coding RNAs are differentially expressed in the islets of obese mice.•The level of two islet long non-coding RNAs correlates to body weight and glycemia.•The expression of these islet long non-coding RNAs is altered in Type 2 diabetes.•Altered expression of these long non-coding RNAs sensitise β-cells to apoptosis.

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关键词

Diabetes,Insulin,Pancreatic islet,Obesity,Gene expression

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