Post-exposure treatment with the oxime RS194B rapidly reactivates and reverses advanced symptoms of lethal inhaled paraoxon in macaques.

Yvonne J Rosenberg, Jerry Wang, Tara Ooms,Narayanan Rajendran,Lingjun Mao,Xiaoming Jiang,Jonathan Lees,Lori Urban,Jeremiah D Momper,Yadira Sepulveda,Yan-Jye Shyong,Palmer Taylor

Toxicology Letters（2018）

引用 34|浏览21

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摘要

•Macaque model to demonstrate clinical symptoms following inhaled or ingested insecticide.•Efficacy of blood-brain penetrant RS194B oxime as a post exposure treatment.•Rapid reactivation of paraoxon-inhibited AChE and BChE in blood by RS194B.•Rapid reversal of paraoxon-induced advanced clinical symptoms by RS194B.

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关键词

AChE,BChE,Ma,OP,Px,IM

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