A ubiquitin-dependent signalling axis specific for ALKBH-mediated DNA dealkylation repair

Joshua R. Brickner,Jennifer M. Soll,Patrick M. Lombardi,Cathrine B. Vågbø,Miranda C. Mudge,Clement Oyeniran,Renana Rabe,Jessica Jackson,Meagan E. Sullender, Elyse Blazosky,Andrea K. Byrum,Yu Zhao,Mark A. Corbett,Jozef Gécz,Michael Field,Alessandro Vindigni,Geir Slupphaug,Cynthia Wolberger,Nima Mosammaparast

NATURE（2017）

引用 91|浏览46

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摘要

signalling mechanism in human cells for sensing DNA damage induced by alkylation involves ubiquitin-dependent recruitment of the alkylation repair complex ASCC to the vicinity of the damage and co-localization with transcription and splicing factors.

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关键词

DNA damage response,Ubiquitylation,Science,Humanities and Social Sciences,multidisciplinary

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