Heterodimeric Diterpenoids Isolated From Euphorbia Ebracteolata Roots And Their Inhibitory Effects On Alpha-Glucosidase

Two heterodimeric diterpenoids (1 and 2) comprising abietane lactone and nor-rosane constituent units were isolated from Euphorbia ebracteolata roots. Compound 1 exhibited a moderate inhibitory effect on alpha-glucosidase (IC50= 7.94 mu M), with a K-i value of 10.8 mu M. In silico molecular docking has been performed to investigate the inhibition mechanism. Compound 2 inhibited the acetyl transfer activity of Mycobacterium tuberculosis GlmU (IC50 = 41.85 mu M), which is a novel tuberculosis treatment target.