Inflammatory Molecule Reduction With Hydroxyurea Therapy In Children With Sickle Cell Anemia

Rhiannon R. Penkert,Julia L. Hurwitz,Paul Thomas,Jason Rosch,Jola Dowdy,Yilun Sun,Li Tang,Jane S. Hankins

HAEMATOLOGICA（2018）

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摘要

Children with sickle cell anemia (SCA) suffer from a chronic state of inflammation due to repeated tissue insult from sickling red blood cells. The clinical consequences are severe and involve aberration of inflammatory systems, with associated increased activation of multiple cell types, including

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