Inhibition of Advanced Glycation Endproduct (AGE) Rescues against Streptozotocin-Induced Diabetic Cardiomyopathy: Role of Autophagy and ER Stress.

Toxicology Letters(2018)

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摘要
•We examined the effect of aminoguanidine on diabetes-induced cardiac anomalies.•Aminoguanidine rescues diabetes-induced cardiac remodeling and contractile anomalies.•The effect of aminoguanidine was related to autophagy induction and inhibition of ER stress.
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关键词
Diabetes,Advanced glycation endproduct (AGE),Cardiac,Autophagy,ER stress
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