Detection of Complexes in Biological Networks Through Diversified Dense Subgraph MiningEIWOS

摘要

Protein-protein interaction (PPI) networks, providing a comprehensive landscape of protein interaction patterns, enable us to explore biological processes and cellular components at multiple resolutions. For a biological process, a number of proteins need to work together to perform a job. Proteins densely interact with each other, forming large molecular machines or cellular building blocks. Identification of such densely interconnected clusters or protein complexes from PPI networks enables us to obtain a better understanding of the...更多
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Journal of Computational Biology, Volume 24, Issue 9, 2017, Pages 923-941.

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