Conjugated polymer containing organic radical for optical/MR dual-modality bioimaging.

Optical/MRI bimodal probes have attracted much attention attribute to palmary soft tissue resolution and high imaging sensitivity. In this study, poly[fluorene-co-alt-p-phenylene] containing organic radical (PFP-TEMPO+) is successfully developed for optical and MRI dual-modality bioimaging. PFP-TEMPO+ displays advanced properties such as fluorescence emission, high photostablilty, reasonable T1 relaxation effect, low cytotoxicity, and good biocompatibility. Moreover, imaging of tumor tissues of PFP-TEMPO+ in vivo confirms that PFP-TEMPO+ could be used as optical and MRI imaging probe for in vivo imaging. The results of the present work disclose PFP-TEMPO+ with potential broad applications as optical and MRI contrast agent.