Hypermethylated ZNF582 and PAX1 genes in oral scrapings collected from cancer-adjacent normal oral mucosal sites are associated with aggressive progression and poor prognosis of oral cancer

Shih-Jung Cheng,Chi-Feng Chang,Hui-Hsin Ko,Yi-Ching Liu,Hsin-Hui Peng,Huei-Jen Wang,Hsiao-Shan Lin,Chun-Pin Chiang

Oral Oncology（2017）

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摘要

•Hypermethylated ZNF582 and PAX1 in normal oral cells predict cancer progression.•Hypermethylated ZNF582 and PAX1 in normal oral cells predict cancer prognosis.•Hypermethylated ZNF582 and ZNF582/PAX1 are independent poor prognostic factors.

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关键词

ZNF582,PAX1,DNA methylation biomarker,Oral squamous cell carcinoma

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