A Multigene Signature Based on Cell Cycle Proliferation Improves Prediction of Mortality Within 5 Yr of Radical Nephrectomy for Renal Cell Carcinoma.

A previously established, tissue-based molecular classifier predicted recurrence and mortality after radical nephrectomy, adding prognostic information beyond a validated clinical nomogram. A composite clinical and molecular score was developed, which accurately categorized patients according to their likelihood of mortality.