A computational model-based approach for atlas construction of aortic Doppler velocity profiles for segmentation purposes.

•A framework that couples circulation model and atlas construction method is proposed.•The model quickly simulates virtual patients with diverse conditions of aortic valve.•Their Doppler images are obtained via fluid dynamics and imaging modality properties.•The atlas created from simulated images was applied for segmenting clinical images.•Applied atlas construction method proves favorable for heterogeneous conditions.