Histone deacetylase inhibitor (HDACi) upregulates activin A and activates the Smad signaling pathway in melanomas.

Journal of Dermatological Science（2018）

引用 7|浏览6

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摘要

•SAHA treatment inhibited melanoma cell proliferation.•Conditioned medium from SAHA-treated SK-Mel-5 cells enhanced Smad signaling pathway.•Activin A could be a key constituent of the SAHA-treated conditioned medium.

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关键词

Melanoma,SAHA,R-Smad,Activin A,Secretome

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