Efficient loading of ethionamide in cyclodextrin-based carriers offers enhanced solubility and inhibition of drug crystallization

Jitendra Wankar,Giuseppina Salzano,Elisabetta Pancani,Gabor Benkovics,Milo Malanga,Francesco Manoli,Ruxandra Gref,Eva Fenyvesi,Ilse Manet

International Journal of Pharmaceutics（2017）

引用 14|浏览25

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摘要

Α βCyD-epichlorohydrin crosslinked polymer organised in nanoparticles of ca. 15nm size is able to solubilize the anti-tuberculosis drug Ethionamide up to 25mM in water.

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关键词

Ethionamide (PubChem CID: 2761171),Isothiocyanatofluorescein (PubChem CID: 18730),β-Cyclodextrin (PubChem CID: 444041)

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