Colloidal aggregation: From screening nuisance to formulation nuance

•Colloidal aggregates form above a critical aggregation concentration, yet can be re-solubilized to monomers with detergents.•The formation of colloidal drug aggregates impact biological outcomes.•Colloidal aggregates can lead to false positives in drug screens.•Current efforts to stabilize and exploit colloidal drug aggregates are highlighted.