Usability evaluation of a medication reconciliation tool: Embedding safety probes to assess users’ detection of medication discrepancies

•We evaluated a collaborative, provider-patient medication reconciliation tool.•Usability scenarios included real and fictional components with safety probes.•Safety probes captured clinically-focused usability outcomes.•Results show the value of assessing usability prior to clinical research trials.•More prevalent use of safety probes could strengthen usability research.