Ultra-low Carbon Dioxide Partial Pressure Improves the Galactosylation of a Monoclonal Antibody Produced in Chinese Hamster Ovary Cells in a Bioreactor

Chen Wang,Jiaqi Wang,Min Chen,Li Fan,Liang Zhao,Wen-Song Tan

Biotechnology letters（2018）

引用 5|浏览17

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摘要

To explore the influence of ultra-low carbon dioxide partial pressure (pCO2) on the monoclonal antibody (mAb) N-glycosylation profile in Chinese hamster ovary (CHO) cell culture.

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关键词

Chinese hamster ovary cell,Glycosylation,pCO2,Scale-up,Monoclonal antibody

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