A Novel Computational Model of the Human Sinoatrial Action Potential

Alan Fabbri,Matteo Fantini,Ronald Wilders,Stefano Severi

2015 Computing in Cardiology Conference (CinC)（2015）

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摘要

The sinoatrial node (SAN) tissue is responsible for the heart rhythm in physiological conditions. SAN cells are self-oscillating and the phenomena underlying this feature are well-described through electrophysiological experiments carried out on animals. Recently, human SAN cell data were recorded, but a human SAN action potential (AP) mathematical model is still lacking.

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关键词

human sinoatrial action potential,heart rhythm,physiological conditions,SAN cells,electrophysiological experiments,SAN cell data,human SAN action potential mathematical model,human SAN AP model,Severi-DiFrancesco SAN model,funny current,AP waveform,calcium transient,pacemaker activity,drug effects

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