Integrated genome regulation of brain development: targeting ontogenomic networks in schizophrenia via nanomachine-genome optical communications.

Major breakthroughs in the field of genomics, embryonic stem cell (ESC) biology, optogenetics and biophotonics are enabling the control and monitoring of biological processes through light. By incorporating light-actuated/light-emitting proteins into cells, key biological processes at the sub-cellular level can be controlled and monitored in real time. This article describes a new type panon-togenic, i.e., affecting the entire ontogeny or development of an individual organism from its earliest stage to maturity, regulation of the developmental genome and the perspective for its control with nanomachines through optical communication.