Resolution-Enhanced Lensless Color Shadow Imaging Microscopy Based on Large Field-of-View Submicron-Pixel Imaging Sensors.

We report a resolution-enhanced lensless color shadow imaging microscopy (RELCSIM) system based on large field-of-view (FOV) submicron-pixel imaging sensors. The physical pixel size of our custom made imaging chip is 0.95um x 0.95um, and the pixel-count is 25 millions (5120H x 5120V). By directly recording the shadow of the samples without any postprocssing, we have realized a microscope with a half-pitch resolution of similar to 1um and a FOV of similar to 25mm(2) simutaneously. To verify the resolution of our system, the grating samples coated on the surface of the chip are imaged. We further demonstrate the monochromatic and color shadow imaging of muscle tissue specimens with the prototype, which show the potential for applications such as diagnostic pathology.