Development of a pharmacodynamic biomarker to measure target engagement from inhibition of the NGF-TrkA pathway.

Eric A Price,Alicja Krasowska-Zoladek,Kausik K Nanda,Shawn J Stachel,Darrell A Henze

Journal of Neuroscience Methods（2017）

引用 2|浏览17

暂无评分

摘要

•Optimized skin and brain protein extraction methods.•Development of custom rodent and human phospho-Trk ELISA assays.•Determination of TrkA target engagement correlated with efficacy in a preclinical rodent model of pain.•Pilot work for translation to clinical use in human skin biopsies.

查看译文

关键词

TrkA (tropomyosin receptor kinase),NGF (nerve growth factor),Pharmacodynamic biomarker,Rodent pain model,Neurotrophin,Enzyme-linked immunosorbent assays (ELISAs)

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要