Immunomodulatory Effects of Tyrosine Kinase Inhibitor In Vitro and In Vivo Study.

Elena Marinelli Busilacchi,Andrea Costantini,Nadia Viola,Benedetta Costantini,Jacopo Olivieri,Luca Butini,Giorgia Mancini,Ilaria Scortechini,Martina Chiarucci,Monica Poiani,Antonella Poloni,Pietro Leoni,Attilio Olivieri

Biology of Blood and Marrow Transplantation（2018）

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摘要

•TKIs suppress the production of proinflammatory cytokines in vitro, including IL-17.•TKIs reduce the frequency of total Tregs in vitro but preserve naive subsets.•B and NK cells are impaired by TKIs in vitro, whereas T cells are preserved.•Comparable results were obtained in patients treated with nilotinib for cGVHD.

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关键词

Tyrosine kinase inhibitors (TKIs),Chronic graft-versus-host disease (cGVHD),Lymphocyte subpopulations,T regulatory cells,Cytokine production

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