Pharmacokinetics and tissue distribution study of 10-methoxycamptothecin in rats following intragastric administration.

Jian Zheng, Yong Ji,Changmin Shao,Lijia Jing,Yang Wang

Journal of Pharmaceutical and Biomedical Analysis（2018）

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摘要

•A UPLC–MS/MS assay was developed for simultaneous quantification of MCPT and HCPT.•The validated method was successfully applied to the pharmacokinetic study.•MCPT concentration in lung tissue was much higher than that in other test tissues.

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关键词

10-methoxycamptothecin,10-hydroxycamptothecin,UPLC–MS/MS,Oral bioavailability

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