The Vietnamese pig as a translational animal model to evaluate tissue engineered heart valves: promising early experience.
INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS(2017)
摘要
Several animal models are currently used for the surgical implantation of either biologic or biopolymeric scaffolds in order to provide in vivo assessment of tissue-engineered heart valves. The Vietnamese pig (VP) is herein proposed as a suitable recipient to test the function of novel bioengineered valve substitutes, in the reconstruction of the right ventricular outflow tract (RVOT). This review aims to provide a complete and exhaustive panel of physiological parameters and methodological information for preclinical studies of tissue-engineered heart valves in the VP animal model.
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关键词
Animal model,Decellularization,Preclinical study,Tissue engineered heart valve,Vietnamese pig
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