Immunogenicity of live attenuated Japanese encephalitis SA 14-14-2 vaccine among Sri Lankan children with previous receipt of inactivated JE vaccine.

Pushpa Ranjan Wijesinghe,M R Nihal Abeysinghe,Sutee Yoksan,Yafu Yao,Benli Zhou,Lei Zhang,Jessica A Fleming,Anthony A Marfin,John C Victor

Vaccine（2016）

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摘要

Administration of CD-JEV to these children with pre-existing neutralizing JE antibody titers was safe and resulted in substantial boosting of antibody levels. These results may inform other countries in Asia considering switching from IMBV to now WHO-prequalified CD-JEV vaccine to combat this disease of public health importance.

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关键词

Japanese encephalitis vaccines,Clinical trial,Humoral immune response,Secondary immune response,Safety

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