Association of TP53 codon 72 and CDH1 genetic polymorphisms with colorectal cancer risk in Bangladeshi population.

Sanzana Fareen Rivu,Mohd Nazmul Hasan Apu,Samia Shabnaz,Noor Ahmed Nahid,Md Reazul Islam,Mir Md Abdullah Al-Mamun,Zabun Nahar,Sikder Nahidul Islam Rabbi,Maizbha Uddin Ahmed,Mohammad Safiqul Islam,Abul Hasnat

Cancer Epidemiology（2017）

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摘要

•This is the first case-control study ever conducted on Bangladeshi colorectal cancer patients in terms of TP53 codon 72 and CDH1 genetic polymorphisms.•Arg/Pro heterozygosity and Pro/Pro mutant homozygosity at codon 72 of TP53 shows a significant association for colorectal cancer predisposition.•A allele and combined genotype of C/A and A/A of CDH1 represent an elevated risk of colorectal cancer development.

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关键词

Colorectal cancer,Genetic polymorphisms,TP53 codon 72,CDH1,Bangladeshi population

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