Xenin-induced feeding suppression is not mediated through the activation of central extracellular signal-regulated kinase signaling in mice

•Xenin increased the number of pERK1/2-immunoreactive cells in the mouse hypothalamus.•Xenin increased pERK1/2 levels in mouse hypothalamic cell lines expressing Ntsr1.•U0126 pre-treatment did not affect xenin-induced feeding suppression in mice.