Evaluation of the Role of Laparoendoscopic Single-Site Surgery Vs Minilaparoscopy for Treatment of Upper Urinary Tract Pathologies: Prospective Randomized Comparative Study

Objectives: To present the first prospective randomized comparison between laparoendoscopic single-site surgery (LESS) and minilaparoscopy (ML) for treatment of upper urinary tract pathologies. Patients and Methods: Between January 2013 and June 2015, patients with different upper urinary pathologies were blindly randomized to both LESS and ML. All procedures were done by single experienced surgeon. Both cohorts were compared regarding demographic data, peri and postoperative characteristics, and visual analog pain scale (VAS). Cosmetic outcome was assessed after 12 months using patient scar assessment scale (PSAS) and observer scar assessment scale (OSAS). Results: Sixty patients were randomized into two equal groups with comparable demographic and preoperative characteristics. Indications included nephrectomy, pyeloplasty, cyst marsupialization, adrenalectomy, and repair of retrocaval ureter. Operative time was 16724 and 145 +/- 39 minutes in LESS and ML groups, respectively (p=0.09). Estimated blood loss was 59 +/- 34 and 43 +/- 42mL in both groups, respectively (p=0.2). VAS was 1.7 +/- 0.6 and 2.8 +/- 0.5 in both groups, respectively (p=0.02). PSAS and OSAS were 5.9 +/- 0.85 and 10.6 +/- 1.98 vs 8.9 +/- 0.9 and 13.5 +/- 6.3 in both groups, respectively (p>0.05). There were no intraoperative complications, conversions to open surgery, or conventional laparoscopy in both groups. Mean postoperative Diclofenac Na was 151.7 +/- 35.6 and 169.7 +/- 47.3mg in both groups, respectively (p=0.04). Postoperative complications rate and hospital stay were comparable between both groups. Conclusion: Both LESS and ML have comparable operative time, blood loss, complication rate, and hospital stay in treatment of upper urinary tract pathologies. However, LESS is associated with less analgesic requirement and better cosmetic outcome.