AK03, a new recombinant fibrinogenase prevents abdominal adhesions in a rat model without systemic side effects.

Roman Marius Eickhoff,Andreas Kroh, Klaus Rübsamen,Daniel Heise,Marcel Binnebösel,Uwe Klinge,Ulf Peter Neumann,Christian Daniel Klink

Journal of Surgical Research（2018）

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摘要

The results of this study indicate that the new recombinant fibrinogenase AK03 effectively prevents peritoneal adhesions without causing side effects, notably systemic fibrinogen depletion, bleeding, or impaired wound repair. Due to these results, future clinical studies may be promising.

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关键词

Abdominal adhesion,Fibrinogenase,AK03,Icodextrin

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