NRF2/HO-1 activation via ERK pathway involved in the anti-neuroinflammatory effect of Astragaloside IV in LPS induced microglial cells.

Congjin Li, Fanglin Yang,Feng Liu,Dongbo Li,Tao Yang

Neuroscience Letters（2018）

引用 33|浏览5

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摘要

•ASI inhibited the production of inflammatory mediators in LPS-induced microglial cells.•ASI did not inhibit the MAPK signaling activation.•ASI induced the activaion of NRF2 and HO-1 in BV2 cells.•NRF2/HO-1 activation involved in the anti-inflammatory effect of ASI.•NRF2/HO-1 pathway was up-regulated via ERK activation.

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关键词

Astragaloside IV,Inflammatory,Microglial,NRF2,HO-1

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