Dose-response characteristics of Clematis triterpenoid saponins and clematichinenoside AR in rheumatoid arthritis rats by liquid chromatography/mass spectrometry-based serum and urine metabolomics.

•Metabolomics study of Clematis triterpenoid saponins (TS) and clematichinenoside AR (C-AR) on collagen-induced arthritis rat was investigated.•The Clematis TS and C-AR treatment groups presented a dose-dependent reversal effect on metabolic trajectory and corresponding biomarkers.•45 potential biomarkers were identified in response to RA.•Glycerophospholipid catabolism, sphingolipid metabolism, arachidonic acid metabolism were filtered out as the potential target pathways.